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目的 探讨E -钙黏蛋白 (E -Cad)在肝细胞癌中的表达及其与临床特性之间的关系。方法 采用免疫组化sABC法和E -Cad抗体对 40例肝细胞癌及其相应癌旁组织中的E -Cad的表达进行研究。结果 肝癌组织中E -Cad表达阳性率为 3 0 % ,癌旁组织阳性率表达为93 .3 % ,两者差异有显著性 (P <0 .0 1)。E -Cad的表达与癌TNM分期密切相关 (P <0 .0 1) ,与肿瘤分级有无门静脉癌栓、有无包膜相关 (P <0 .0 5 ) ,与年龄、肿瘤大小无关 (P >0 .0 5 )。结论 E -Cad表达对评价肝细胞癌临床分期有重要意义。检测E -Cad可以判断肝细胞癌生物学行为。
Objective To investigate the expression of E-cadherin (E-cadherin) in hepatocellular carcinoma (HCC) and its relationship with clinical features. Methods Immunohistochemical sABC method and E-Cad antibody were used to study the expression of E-Cad in 40 cases of hepatocellular carcinoma and its corresponding paracancerous tissues. Results The positive rate of E-cadherin expression was 30% in hepatocellular carcinoma tissues and 93.3% in para-carcinoma tissues. The difference was significant (P <0.01). The expression of E-cadherin was closely related to TNM staging of cancer (P <0.01), and was associated with tumor thrombosis with or without portal vein tumor embolus (P <0.05), but not with age and tumor size P> 0 .0 5). Conclusion E-cadherin expression is of great significance in the evaluation of clinical stage of hepatocellular carcinoma. Detecting E-Cad can determine the biological behavior of hepatocellular carcinoma.