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目的研究转ＩＬ┐２基因对Ｓ┐１８０细胞贴壁生长的影响。方法光镜及扫描电镜观察细胞生长的特征。结果转ＩＬ┐２基因的Ｓ１８０细胞为扁平状，并有伪足伸出，微绒毛丰富明显变细变长，并可稳定传代。其余株仍为悬浮生长，细胞呈椭圆球状。结论原为悬浮生长的Ｓ┐１８０细胞，经转入ＩＬ┐２基因后，部分细胞伸出伪足及发生微绒毛变化，是细胞贴壁生长的形态基础。
Objective To study the effect of IL-2 gene transfection on the adherent growth of S┐180 cells. Methods The characteristics of cell growth were observed under light microscope and scanning electron microscope. Results The S180 cells transfected with IL┐2 gene were flat and had pseudopods protruding. The microvilli were obviously thinner and longer, and could be stably passaged. The remaining strains are still suspended growth, the cells were oval-shaped. CONCLUSIONS: Suspension-grown S┐180 cells were transplanted into the IL┐2 gene. Some of them showed pseudopodia and microvilli changes, forming the morphological basis of adherent growth.