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采用ABC免疫组化染色法及单克隆抗体夹心法ELISA，同步检测了34例肾综合征出血热（HFRS）患者外周血T细胞亚群数量和血清白细胞介素2和4（IL－2、IL－4）水平。发现HFRS病程中各T细胞亚群数量均有不同程度的升高，其中CDS阳性T细胞在各病期均有升高。IL－4水平升高仅见于发热期．而IL－2的升高主要在低血压期和少尿期。病程中有CD4／CD8比值的下降甚至倒置。这种比值的变化与IL－2和IL－4的动态变化有一定的相关性。结果揭示，在HFRS发病机理中存在Thl型和Th2型免疫反应等多种免疫病理机制。
ABC immunohistochemical staining and monoclonal antibody sandwich ELISA were used to detect the number of T lymphocyte subsets and IL-2 and IL-2 levels in peripheral blood of 34 patients with HFRS. -4) level. Found that the number of T-cell subsets in HFRS course increased to varying degrees, of which CDS-positive T cells were elevated at all stages. Elevated IL-4 is found only in the fever period. The increase of IL-2 mainly in hypotension and oliguria. The course of the CD4 / CD8 ratio decline or even upside down. This change in the ratio of IL-2 and IL-4 dynamic changes have a certain correlation. The results revealed that in the pathogenesis of HFRS Th1-type and Th2-type immune response and other immune pathology.