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风湿热多见于5～14岁的小儿,经多次反复发作后可形成慢性风湿性心脏病。目前认为诱发风湿热的主要因素是A组乙型溶血性链球菌(以下简称溶链菌)感染。风湿热的发病机理是在溶链菌感染后,某些个体对具有高度抗原性的溶链菌菌体成分及其代谢产物产生了相应的抗体,抗原与抗体相结合形成免疫复合物损伤(组织溶解或破坏),而这些被损伤的组织又可起抗原(自身抗原)作用,于是免疫监视系统使机体又产生相应的抗体(自身抗体),引起自身免疫反应而得病。
Rheumatic fever more common in children aged 5 to 14, after repeated episodes of chronic rheumatic heart disease can form. At present, the main factor that causes rheumatic fever is A group B hemolytic streptococcus (hereinafter referred to as Streptococcus mutans) infection. The pathogenesis of rheumatic fever in the role of Streptococcus mutans infection, some individuals of highly antigenic lysophosphorus bacteria components and their metabolites produced a corresponding antibody, antigen and antibody combine to form immune complex damage (tissue Dissolved or destroyed), and these damaged tissues can act as antigens (autoantigens). Therefore, the immune surveillance system causes the body to produce the corresponding antibodies (autoantibodies), causing the autoimmune reaction to get sick.