论文部分内容阅读
目的:探讨自拟益气活血方治疗小儿脾肾气虚型肾病综合征的临床疗效。方法:选择2014年6月到2016年10月我院收治的80例脾肾气虚型肾病综合征患儿,按随机数字表法分为对照组和治疗组各40例。对照组给予强的松治疗,治疗组在对照组治疗的基础上给予自拟益气活血方治疗,两组均治疗4个月。评估两组临床疗效,检测治疗前后两组24h尿蛋白、总胆固醇(TC)、血浆白蛋白(Alb)以及肾功能指标包括尿素氮(BUN)、血肌酐(Scr)、血肌酐清除率(Ccr)。结果:治疗组的总有效率为95.00%,明显高于对照组的67.50%,差异具有统计学意义(P<0.05)。治疗后,两组24 h尿蛋白、TC、BUN及Scr水平低于治疗前,Alb、Ccr水平高于治疗前,且治疗组上述各指标水平变化均显著优于对照组,差异均具有统计学意义(P<0.05)。结论:自拟益气活血方治疗小儿脾肾气虚型肾病综合征的临床疗效显著,能够明显改善患儿肾功能,值得在临床上推广应用。
Objective: To investigate the clinical efficacy of self-made Yiqi Huoxue Recipe in treating children’s syndrome of spleen-kidney deficiency syndrome. Methods: From June 2014 to October 2016, 80 children with spleen-kidney deficiency syndrome nephrotic syndrome admitted in our hospital were divided into control group and treatment group according to random number table method. The control group was given prednisone, and the treatment group was given self-made Yiqi Huoxue prescription on the basis of the control group. Both groups were treated for 4 months. The clinical efficacy of the two groups was evaluated. The levels of 24 h urinary protein, total cholesterol (TC), serum albumin (Alb) and renal function parameters including BUN, Scr, Ccr ). Results: The total effective rate of the treatment group was 95.00%, which was significantly higher than 67.50% of the control group, the difference was statistically significant (P <0.05). After treatment, the levels of 24 h urinary protein, TC, BUN and Scr in both groups were lower than before treatment, Alb and Ccr levels were higher than those before treatment, and the above indicators in the treatment group were significantly better than the control group, the differences were statistically significant Significance (P <0.05). Conclusion: The clinical efficacy of Yiqi Huoxue Recipe in treating children with spleen-kidney-qi deficiency syndrome nephrotic syndrome is significant, which can significantly improve renal function in children, which is worth popularizing and applying in clinic.