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背景:麻疹、腮腺炎和风疹(MMR)疫苗接种后高热惊厥的发生率增高,这种增高是否与个人或者家族癫痫病史、围生期因素以及社会经济状况有关,目前尚不清楚。此外,对于疫苗接种后出现高热惊厥的长期预后也知之甚少。目的:对儿童多个亚群进行MMR疫苗接种后出现高热惊厥的危险度(RRs)和危险性进行测定,对MMR疫苗接种后出现高热惊厥的临床预后进行评估。设计、机构及受试者:采用总体定群研究,所有受试儿童均出生自丹麦,时间为1991年1月1日至1998年12 月31日,出生3个月后生存者。我们对537171名儿童
Background: The incidence of febrile seizures following measles, mumps and rubella (MMR) vaccination is increasing, and it is unclear whether this increase is related to the history of individuals or family history of epilepsy, perinatal factors, and socioeconomic status. In addition, little is known about the long-term prognosis of febrile seizures following vaccination. OBJECTIVE: To determine the risk of febrile seizures (RRs) and risk after multiple MMR vaccination in children with multiple subgroups and to assess the clinical prognosis of febrile seizures following MMR vaccination. DESIGN, INSTITUTIONS AND SUBJECTS: All cohorts were studied. All children were born in Denmark from January 1, 1991 to December 31, 1998 and survived 3 months after birth. We are 537,171 children