Cyclooxygenase-2 and epithelial growth factor receptor up-regulation during progression of Barrett&#

• 作 者: John M Wo Mukunda B Ray Whitney Jones Ruifeng R Su Susan Ellis Robert C G Martin
• 机 构: Division of Gastroenterology/Hepatology University of Louisville School of Medicine Louisville,KY 40
• 出 处: World Journal of Gastroenterology
• 发表日期: 2006年06期
• 关键词: Barrett esophagus progression adenocarcinoma carcinogenesis metaplasia dysplasia

AIM:To investigate the expression of cyclooxygenase-2(COX-2)and epithelial growth factor receptor(EGFR)throughout the progression of Barrett’s esophagus(BE).METHODS:COX-2 and EGFR protein expressions weredetected by using immunohistochemical method.Adetailed cytomorphological changes were determined.Areas of COX-2 and EGFR expression were quantified byusing computer Imaging System.RESULTS:The expressions of both COX-2 and EGFRincreased along with the progression from BE to esophagusadenocarcinoma(EAC).A positive correlation was foundbetween COX-2 expression and EGFR expression.CONCLUSION:COX-2 and EGFR may be cooperativein the stepwise progression from BE to EAC,therebyleading to carcinogenesis.

AIM: To investigate the expression of cyclooxygenase-2 (COX-2) and epithelial growth factor receptor (EGFR) throughout the progression of Barrett’s esophagus (BE). METHODS: COX-2 and EGFR Protein expressions weredetected by using immunohistochemical method. changes were determined.Areas of COX-2 and EGFR expression were quantified byusing computer Imaging System. RESULTS: The expressions of both COX-2 and EGFR increased by along the progression from BE to esophagus adenocarcinoma (EAC). A positive correlation was found between COX-2 expression and EGFR expression. CONCLUSION: COX-2 and EGFR may be cooperative in the stepwise progression from BE to EAC, there is prevalent to carcinogenesis.