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目的:观察体外循环所致先心心病儿童血小板激活及抑肽醉的保护作用。方法:20例非紫绀性心脏病儿童随机分为两组，A组（n=10）使用抑肽防，按5×X105IU／kg的剂量加入预充液中;B组（n=10）不用抑肽酶。检测血浆P-选择素、血栓素B2、肌酐、尿索氮、血小板计数及血球压积，记录输血总量、术中、术后24h失血量。结果:体外循环期间P-选择素和血栓素B2较转流前升高，A组明显低于B组（P＜0.05），术中、术后24h输血量、失血量，A组明显少于B组（P＜0.05）。血小报计数、肌酐及尿素氮两组无显著差异。结论:儿童体外循环可导致血小板激活，P-选择素释放增加，血栓素B2升高，血小板减少，抑肽酶可减轻血小板激活，抑制释放反应，保护血小板功能，减少术中、术后输血量和失血量。
Objective: To observe the protective effect of platelet activation and aprotinin on children with congenital heart disease during cardiopulmonary bypass. Methods: Twenty children with non-cyanotic heart disease were randomly divided into two groups. Group A (n = 10) was treated with aprotinin at a dose of 5 × 10 5 IU / kg, while group B (n = 10) Aprotinin. Plasma P-selectin, thromboxane B2, creatinine, urinary cable nitrogen, platelet count and hematocrit were measured. The total amount of blood transfusion was recorded, and the amount of blood loss during and after surgery was recorded. Results: P-selectin and thromboxane B2 increased during cardiopulmonary bypass compared with those before the switch, and were significantly lower in group A than in group B (P <0.05). Intraoperative and postoperative 24h blood transfusion, blood loss were significantly less in group A Group B (P <0.05). Blood tabloid count, creatinine and urea nitrogen no significant difference between the two groups. Conclusion: Cardiopulmonary bypass can lead to platelet activation, increased P-selectin release, thromboxane B2 increase, thrombocytopenia, aprotinin can reduce platelet activation, inhibition of release response, protection of platelet function, reduce intraoperative and postoperative blood transfusion And blood loss.