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目的探讨糖代谢异常在高血压视网膜病变发生过程中的作用，为临床预防和治疗高血压视网膜病变提供理论依据。方法应用酶组织化学方法对正常京都种大鼠和自发性高血压大鼠视网膜组织的葡萄糖－６－磷酸脱氢酶、琥珀酸脱氢酶和乳酸脱氢酶的活性变化进行观察比较。结果在正常大鼠视网膜组织中，葡萄糖－６－磷酸脱氢酶以杆锥层活性最强，其他各层活性基本一致，琥珀酸脱氢酶主要分布在杆锥层内节，乳酸脱氢酶主要分布在内网层、节细胞层和神经纤维层。在高血压大鼠视网膜组织中，葡萄糖－６－磷酸脱氢酶和琥珀酸脱氢酶活性减弱，乳酸脱氢酶活性增强。结论高血压发生后，视网膜组织糖代谢发生障碍是高血压视网膜损伤的重要原因之一。
Objective To investigate the role of abnormal glucose metabolism in the development of hypertensive retinopathy and provide a theoretical basis for clinical prevention and treatment of hypertensive retinopathy. Methods The changes of glucose-6-phosphate dehydrogenase, succinate dehydrogenase and lactate dehydrogenase activity in retina of normal Kyoto rats and spontaneously hypertensive rats were observed and compared by enzyme histochemistry. Results In the normal rat retina tissue, glucose-6-phosphate dehydrogenase had the strongest activity in the cone layer and the other layers were basically the same. The succinate dehydrogenase mainly distributed in the inner part of the rod cone, the lactate dehydrogenase Mainly distributed in the network layer, cell layer and nerve fiber layer. In hypertensive rat retinas, glucose-6-phosphate dehydrogenase and succinate dehydrogenase activity decreased, lactate dehydrogenase activity increased. Conclusion Hypertension occurs after retinal tissue glucose metabolism disorder is one of the important causes of hypertension retinal damage.