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目的:调查重庆地区健康体检人群中幽门螺旋杆菌(Helicobacter pylori,Hp)感染率和人群分布情况,分析Hp感染的相关危险因素,为Hp感染及相关并发症的预防和治疗提供数据支持。方法:采用~(13)C尿素呼气试验筛查重庆医科大学附属第一医院10 912例体检者Hp的感染情况,比较不同年龄段和性别间Hp感染的差异;收集体格检查和生化检查资料,通过logistic回归分析Hp感染的潜在危险因素。结果:(1)通过对体检人群的临床资料及生化指标的分析,结果显示:Hp感染组的年龄、总胆固醇、低密度脂蛋白、空腹血糖显著高于未感染组;同时,感染组的血清白蛋白低于未感染组。(2)Hp的人群感染率为34.37%(3 750/10 912),其中男性和女性体检人群的感染率分别为33.75%和35.05%(χ~2=2.030,P=0.154)。(3)通过年龄和性别分层,结果显示:60岁之前,男女性别间感染无差异;60岁以后,男性感染率明显高于女性(P<0.000);男性和女性的感染率随年龄呈上升趋势。(4)Logistic回归分析显示,年龄、白蛋白和空腹血糖与Hp感染显著相关(P<0.05)。其中,年龄增长和高血糖症是Hp感染的危险因素(OR>1,P<0.05),血浆高水平白蛋白是预防Hp感染的保护因素(OR<1,P<0.05)。结论:重庆地区普通体检人群Hp的感染率较高,且感染率随年龄的增长呈现增高的趋势;增长的年龄、血浆高水平白蛋白(白蛋白≥48 g/L)和高血糖症与Hp感染显著相关。应开展针对性措施预防Hp感染并进行根治,减少其远期并发症的发生。
Objective: To investigate the prevalence and distribution of Helicobacter pylori (Hp) among healthy people in Chongqing and to analyze the related risk factors of Hp infection and provide data support for the prevention and treatment of Hp infection and related complications. Methods: The prevalence of Hp infection in 10 912 HCC patients in the First Affiliated Hospital of Chongqing Medical University was screened by ~ (13) C urea breath test, and the differences of Hp infection among different age groups and genders were compared. Physical examination and biochemical examination data Logistic regression analysis of potential risk factors for Hp infection. Results: (1) Through the clinical data and biochemical analysis of the physical examination population, the results showed that the age, total cholesterol, low density lipoprotein, fasting blood glucose were significantly higher in Hp infection group than in non-infected group; meanwhile, Albumin was lower than the non-infected group. (2) The prevalence of Hp infection was 34.37% (3 750/10 912). The prevalence rates of H.pylori were 33.75% and 35.05%, respectively (χ ~ 2 = 2.030, P = 0.154). (3) By age and gender stratification, the results showed that there was no difference between male and female before 60 years of age. After 60 years of age, the male’s infection rate was significantly higher than that of female (P <0.000). The infection rate of men and women with age was Upward trend. (4) Logistic regression analysis showed that age, albumin and fasting blood glucose were significantly associated with Hp infection (P <0.05). Among them, age and hyperglycemia were risk factors for Hp infection (OR> 1, P <0.05). Plasma high-level albumin was a protective factor against Hp infection (OR <1, P <0.05). Conclusion: The infection rate of Hp in general medical examination population in Chongqing is high, and the infection rate tends to increase with age. The increasing age, high serum albumin (albumin ≥48 g / L), hyperglycemia and Hp Infection was significantly related. Targeted measures should be carried out to prevent and cure Hp infection and reduce the occurrence of its long-term complications.