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一次大量吞服异烟肼可导致急性中毒。我院自1965年5月～1979年8月共收治急性异烟肼中毒14例,兹分析如下:男5例,女9例。年龄22～55岁。一次服量4克～25克(平均10.25克),2例剂量不明。症状均发生在服药后1～2(1/2)小时内。临床表现首发症状为恶心呕吐者7例。除1例外均有抽搐,3例癫痫样尖叫后,昏倒在地,随即抽搐。昏迷10例。紫绀与心动过速各9例。发热8例,体温均在38℃—40℃之间。
A large number of ingestion of isoniazid can cause acute poisoning. Our hospital from May 1965 to August 1979 were treated for acute isoniazid in 14 cases, the analysis is as follows: 5 males and 9 females. Age 22 ~ 55 years old. A dose of 4 grams to 25 grams (an average of 10.25 grams), two doses unknown. Symptoms occurred in the medication after 1 ~ 2 (1/2) hours. The first symptom of clinical manifestations was nausea and vomiting in 7 cases. All but one had convulsions. After three cases of epileptiform screams, they collapsed to the ground and then twitched. Coma in 10 cases. Cyanosis and tachycardia in 9 cases. Fever in 8 cases, body temperature were between 38 ℃ -40 ℃.