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目的：用小白鼠进行急性毒性试验，以确定拮氟锐的毒性等级和提供其慢性毒性试验依据。方法：用灌胃法给药；观察小白鼠不同时间的各种表现；用改良Ｋǎｒｂｅｒ法计算拮氟锐的半数致死剂量。结果：低剂量组动物灌胃后未见明显变化，其它剂量组动物均出现死亡；观察见有激惹状态、皮肤潮红、腹泻、粪便带血等现象；拮氟锐的半数致死剂量为２９５５６ｍｇ／ｋｇ。结论：拮氟锐属微毒，动物的急性中毒主要表现为硼砂和锌的中毒症状。
OBJECTIVE: To conduct acute toxicity test in mice to determine the toxicity grade of TEF and provide the basis for its chronic toxicity test. Methods: Gavage administration; observation of various performance of mice at different times; using modified Kǎrber method to calculate the half-lethal dose of arrhythmia. Results: The animals in the low dose group showed no significant changes after gavage, and the animals in the other dose groups all died. The symptoms of irritation, skin flushing, diarrhea and bloody stool were observed. The median lethal dose of tacrolimus was 29556 mg / kg. Conclusion: Antagonism of Fluoride is a micro-poisoning animal acute poisoning mainly manifested as borax and zinc poisoning symptoms.