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[目的]研究膜联蛋白A5(Annexin A5)在结肠腺癌组织中的表达水平及其与临床病理因素之间的关系。[方法]应用蛋白质印迹法(Western blot)和S-P免疫组化法检测结肠腺癌组织和相应癌旁正常组织中Annexin A5表达状况。[结果]Annexin A5在结肠腺癌组织中的表达水平及阳性表达率均显著高于相应癌旁正常组织中的表达,差异具有显著性(P<0.05)。进一步研究表明,Annexin A5表达与肿瘤大小和患者是否发生淋巴结转移有关(P<0.05)。[结论]Annexin A5在结肠腺癌的形成和转移中有着重要作用,有望成为结肠腺癌临床治疗的新靶标。
[Objective] To investigate the expression of Annexin A5 in colon adenocarcinoma and its relationship with clinicopathological factors. [Method] The expression of Annexin A5 in colon adenocarcinoma and adjacent normal tissues was detected by Western blot and S-P immunohistochemistry. [Results] The positive expression rate of Annexin A5 in colon adenocarcinoma was significantly higher than that in corresponding normal tissues (P <0.05). Further studies showed that Annexin A5 expression was correlated with tumor size and lymph node metastasis (P <0.05). [Conclusion] Annexin A5 plays an important role in the formation and metastasis of colon adenocarcinoma and is expected to become a new target for the clinical treatment of colon adenocarcinoma.