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目的分析研究硝苯地平联合卡托普利治疗高血压的临床效果。方法硝苯地平10mg,3次/d,卡托普利25mg,2次/d,然后根据血压每周递增25mg/d,最大剂量150d,尽量使血压稳定在≤140/90mmHg,发现血压低至140/90mmHg,则减量,5周为一疗程。结果本组56例,血压由平均(180±12)/(110±5)mmHg。下降至140/90mmHg。经自身对照t检验,P均<0.01。显效48例,占85.71%;有效6例,占10.71%;无效2例,占3.57%;总有效率96.43%。结论硝苯地平联合卡托普利治疗高血压可以起到协同降压作用,提高疗效;同时能降低副作用,特别是对伴有并发症的高血压患者则是较佳治疗方案。
Objective To analyze the clinical effect of nifedipine combined with captopril in the treatment of hypertension. Methods nifedipine 10mg, 3 times / d, captopril 25mg, 2 times / d, then according to blood pressure weekly increased 25mg / d, the maximum dose of 150d, try to make blood pressure stabilized at ≤ 140/90 mmHg, found that blood pressure is low 140 / 90mmHg, then reduce, 5 weeks for a course of treatment. Results The group of 56 patients, the average blood pressure (180 ± 12) / (110 ± 5) mmHg. Drop to 140 / 90mmHg. By self-control t test, P <0.01. 48 cases were markedly effective, accounting for 85.71%; 6 cases were effective, accounting for 10.71%; 2 cases were ineffective, accounting for 3.57%; and the total effective rate was 96.43%. Conclusion Nifedipine combined with captopril treatment of hypertension can play a synergistic antihypertensive effect to improve the curative effect; at the same time can reduce the side effects, especially for patients with complications of hypertension is the preferred treatment.