儿童慢性炎症性脱髓鞘多神经病变:甲基泼尼松龙冲击治疗的预后(法)

• 作 者: Rafai M.A Moutaouakil F ElOtmani H 赵天智
• 机 构: Service de Neurologie Pavillon 30 Quartier des Hpitaux,Casablanca Morocco,
• 出 处: 世界核心医学期刊文摘(神经病学分册)
• 发表日期: 2006年11期
• 关键词: 多神经病 脱髓鞘 慢性炎症 行走障碍 电生理学 剂量 于儿 静脉输注 预后良好 甲基泼尼松龙

Introduction. Chronic inflammatory demyelinating polyneuropathy (CIDP) in children is relatively rare and treatment is based primarily on intravenous immunoglobulins or oral corticosteroids. Boluses of methylprednisolone (MP) are a seldom used alternative. Case report. We report the case of an 8-year-old child, first presented at the age of 3 years, with recurring episodes of functional impotence of both lower limbs and walking impairment, partially reversible without treatment. Clinical, progressive, and electrophysiological data and the analysis of the cerebrospinal fluid were compatible with CIDP. MP boluses were administered: after a total eight monthly boluses, very satisfactory progression on the clinical and electrophysiological fronts was noted after 24 months. Conclusion. Childhood CIDP presents clinical, electrophysiological, progressive, and prognostic particularities, they recur readily and the outcome is good. Boluses of methylprednisolone are an alternative to the treatment of these neuropathies in childhood.

Introduction. Chronic inflammatory demyelinating polyneuropathy (CIDP) in children is relatively rare and treatment is based primarily on intravenous immunoglobulins or oral corticosteroids. Boluses of methylprednisolone (MP) are a seldom used alternative. Case report. We report the case of an 8-year -old child, first presented at the age of 3 years, with recurring episodes of functional impotence of both lower limbs and walking impairment, partially reversible without treatment. Clinical, progressive, and electrophysiological data and the analysis of the cerebrospinal fluid were compatible with CIDP After a total eight monthly boluses, very satisfactory progression on the clinical and electrophysiological fronts was noted after 24 months. Conclusion. Childhood CIDP presents clinical, electrophysiological, progressive, and prognostic particularities, they recur readily and the outcome is good. Boluses of methylprednisolone are an alternative to the treatme nt of these neuropathies in childhood.