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作者根据肺活检组织学和免疫荧光检查结果,分析42例(急性经过者3例,慢性经过者39例)特发性纤维化性肺泡炎的免疫形态学变化。3例急性者的组织学检查所见:肺泡隔肿胀,毛细血管充血,血管内皮增生,间质水肿。肺泡隔有多种炎细胞浸润,肺泡腔有大量巨噬细胞和脱落的肺泡上皮。组织切片免疫荧光检查所见:3例血管内皮都有IgG 和免疫复合物沉积.外周血免疫复合物、抗核抗体、抗肺抗体以及免疫球蛋白含量增高。每个病人都有5～6项体液免疫指标异常。39例慢性者的免疫形态学的变化:变化很明显
According to the results of lung biopsy and immunofluorescence, the authors analyzed the immunomorphological changes of idiopathic fibrosing alveolitis in 42 patients (3 acutely-treated and 39 chronic-refractory). 3 cases of acute histological examination showed: alveolar septal swelling, capillary congestion, vascular endothelial proliferation, interstitial edema. Alveolar septum has a variety of inflammatory cell infiltration, alveolar cavity with a large number of macrophages and shed alveolar epithelium. Immunofluorescence examination of tissue sections revealed that IgG and immune complexes were deposited in all three cases of vascular endothelium, with increased levels of peripheral immune complexes, antinuclear antibodies, anti-pulmonary antibodies and immunoglobulins. Each patient has 5 to 6 humoral immune abnormalities. Changes in immunomorphology in 39 patients with chronic conditions: The changes were significant