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目的 :观察中药颗粒分煎与合煎是否存在疗效、药效不同差异。方法 :采用自拟复方健胃舒颗粒治疗脾虚肝郁型功能性消化不良患者 10 0例 ,分为分煎组与合煎组各 5 0例 ,对比观察两组临床疗效及药效。结果 :两组临床治愈率分别为 72 %和 70 % ,总有效率均为 96 % ,差异无显著性 (P >0 0 5 ) ;并且两组在抑制大鼠胃酸、胃蛋白酶活性 ,调节小鼠胃功能 ,促进小肠推进度及镇痛药理实验中差异无显著性 (P >0 0 5 )。结论 :健胃舒颗粒分煎与合煎疗效、药效保持一致 ,从一个侧面为单味中药浓缩颗粒在临床辨证施治中 ,灵活配方及加减应用 ,提供科学依据
Objective : To observe whether there are differences in curative effect and efficacy between traditional Chinese medicine granules fried and fried. Methods : Self-made compound Jianweishu granule was used to treat 100 patients with functional dyspepsia of spleen-deficiency and liver-qi stagnation. The patients were divided into separate decoction group and Hejian decoction group. Each group had 50 cases. Clinical efficacy and efficacy were compared between the two groups. Results: The clinical cure rates in the two groups were 72% and 70% respectively, and the total effective rate was 96%. There was no significant difference (P > 0.05). The two groups inhibited gastric acid and pepsin activity in rats, and the adjustment was small. There was no significant difference in mouse stomach function, promotion of small intestinal propulsion and analgesic pharmacological experiment (P > 0 05). Conclusion: Jianweishu granules have the same efficacy and efficacy as fried and fried. From one aspect, the single-flavored Chinese herbal concentrate granules are used in clinical syndrome differentiation treatment. The flexible formula and addition and subtraction application provide scientific basis.