论文部分内容阅读
目的维生素B1辅助治疗T2DM早期肾病,观察尿白蛋白及C反应蛋白(C-RP)的变化。方法 T2DM早期肾病患者108例,随机分为维生素B1治疗组及非维生素B1治疗组,各54例,测血糖、血脂、UAER、C-RP、Fins、HOMA-IR,另选54例健康者和54例单纯T2DM患者作对照。结果两组治疗后,血糖、TG、UAER、C-RP、Fins、HOMA-IR均较治疗前下降,治疗后两组间比较仅UAER、C-RP差异有统计学意义(P<0.01)。结论维生素B1可降低UAER水平,对早期DN患者进行干预后可有效减轻DN白蛋白尿。
Objective To investigate the changes of urinary albumin and C-reactive protein (C-RP) in patients with T2DM early nephropathy. Methods A total of 108 patients with early diabetic nephropathy (T2DM) were randomly divided into the treatment group of vitamin B1 and the non-vitamin B1 treatment group, with 54 cases in each group. Blood glucose, blood lipid, UAER, C-RP, Fins and HOMA- 54 cases of simple T2DM patients as a control. Results After treatment, blood glucose, TG, UAER, C-RP, Fins and HOMA-IR decreased compared with those before treatment. Only UAER and C-RP had statistical significance between the two groups after treatment (P <0.01). Conclusions Vitamin B1 can reduce the level of UAER, which can effectively reduce DN albuminuria after intervention of early DN patients.