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对３２例无先兆型偏头痛的男性飞行员进行血浆血管紧张素Ⅱ（ＡＴＤ－Ⅱ）、强啡肽（ＤＹＮＡ）、Ｐ物质（ＳＰ）、６－酮前列环素（６－ｋｅｔｏ－ＰＧＦ１）、血栓素Ｂ２（ＴＸＢ２）含量的测定，并与３０例健康飞行员对照。结果显示偏头痛组血浆ＡＴ－Ⅱ、ＴＸＢ２升高，６－ｋｅｔｏ－ＰＧＦ１降低，发作期ＤＹＮＡ降低，ＳＰ升高，与对照组比较均Ｐ＜０．０５或０．０１，而间歇期ＤＹＮＡ、ＳＰ无变化。表明偏头痛发作与神经内分泌失调有关，ＡＴ－Ⅱ升高提示肾素－血管紧张素系功能亢进；ＳＰ升高，ＤＹＮＡ降低提示与痛阈降低和对疼痛敏感有关；ＴＸＢ２升高、６－ｋｅｔｏ－ＰＧＦ１．降低表明其血管、血小板功能异常。
Thirty-two male pilots without aura migraine were enrolled in this study. Plasma angiotensin Ⅱ (DYNA), substance P (SP), 6-keto-PGF1, Thromboxane B2 (TXB2) levels were measured and compared with 30 healthy pilots. The results showed that AT-II, TXB2 and 6-keto-PGF1 were decreased in the migraine group, DYNA was decreased and SP was increased in the attack group, P <0.05 or 0.01 compared with the control group, while DYNA, SP no change. This suggests that migraine attacks are associated with neuroendocrine disorders. Elevated AT-II suggests rennin-angiotensin system hyperactivity. Elevated SP, decreased DYNA suggests a decrease in pain threshold and sensitivity to pain; increased TXB2, 6-keto -PGF1. Decrease that its blood vessels, platelet dysfunction.