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阻塞性睡眠呼吸暂停低通气综合征(OSAHS)与高血压密切相关,OSAHS是引起高血压的独立危险因素,但其引起高血压的机制尚未十分清楚。睡眠中长期慢性间断性低氧、高碳酸血症,引起交感活性增加、内皮功能障碍、肾素-血管紧张素-醛固酮系统的激活,以及内皮素1、心钠素分泌的异常增多等都可能是高血压发生的重要因素。OSAHS合并的高血压是一种难治性高血压,单纯的药物治疗很难控制血压平稳,同时应用持续呼吸道正压通气是治疗的最佳方案。
Obstructive sleep apnea-hypopnea syndrome (OSAHS) is closely related to hypertension, OSAHS is an independent risk factor for hypertension, but the mechanism of hypertension is not yet clear. Chronic long-term chronic hypobaric hypoxia, hypercapnia, resulting in increased sympathetic activity, endothelial dysfunction, renin-angiotensin-aldosterone system activation, and endothelin 1, abnormal increase in atrial natriuretic peptide secretion may Is an important factor in the occurrence of hypertension. OSAHS combined hypertension is a refractory hypertension, medication alone is difficult to control blood pressure stability, while the application of continuous positive airway pressure is the best treatment for treatment.