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目的：研究弹力纤维反应对乳腺癌预后的影响．方法：通过对乳腺癌病理切片进行Ｍａｓｓｏｎ、ＶＧ染色并进行光键现察．把乳腺癌弹力纤维反应分为四级０，＋，＋＋，＋＋＋，并根据远离癌区域有无弹力纤维反应分为：周围弹力纤维反应（０）和周围弹力纤维反应（＋）．结果：乳腺病弹力纤维反应阳性（＋～＋＋＋）病例，其淋巴结转移率（５７．６％）明显高于弹力纤维反应阴性病例（１７．１％），两者之间差异有非常显著性（Ｐ＜０．０１）．乳腺癌淋巴结阳性率与弹力纤维分级数呈正相关．周围弹力纤维反应（＋）病例，其淋巴结阳性率（７８．８％）明显高于本组平均淋巴结阳性率（４５．８％）．两者之间差异有非常显著性（Ｐ＜０．０１）．结论：弹力纤维反应可作为乳腺癌预后的一项指标，可能预示乳腺癌的浸润与转移．尤其是远离癌灶区城的弹力纤维反应可能更有意义．
Objective: To study the effect of elastic fiber reaction on the prognosis of breast cancer. Methods: The pathological sections of breast cancer were stained with Masson, VG and spotted by light. The breast cancer elastic fiber reaction is divided into four levels of 0, +, ++, +++, and is divided into elastic fiber reaction (0) and surrounding elastic fiber reaction (+) according to the presence or absence of elastic fiber reaction away from the cancer area. Results: The rate of lymph node metastasis (57.6%) was significantly higher in patients with breast fibroelasticity (+ ~ + + +) than in those with negative elastin (17.1%), the difference was significant P <0.01). The positive rate of lymph node in breast cancer was positively correlated with the number of elastic fibers. Surrounding elastic fiber reaction (+) cases, the positive rate of lymph nodes (78.8%) was significantly higher than the average lymph node-positive rate (45.8%). The difference between the two groups was significant (P <0.01). Conclusion: Elastic fiber reaction can be used as an index of prognosis of breast cancer, which may indicate the infiltration and metastasis of breast cancer. In particular, the elastic fiber response away from the cancerous zone may be more meaningful.