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28例正常健康育龄妇女,自月经来潮后第1～3天起,使用国产促黄体生成激素释放激素(LRH)的激动性类似物,[D-丙~6,去甘酰胺~(10)]-LRH 乙基酰胺(LRH-A)0.5mg/日(10例)和1.0mg/日(18例)经鼻喷雾给药,以连喷21天,停7～10天为一个用药周期的间断给药法,共观察了50个用药周期。结果发现受试者在用药期间E_2、P、和LH 水平均被抑制,无1例妊娠,停药后均能很快恢复正常的排卵周期和性激素水平,亦未见明显毒副反应,似较使用连续给药法为优,故值得临床进一步观察使用。
28 normal healthy women of childbearing age, from the 1st to 3 days after the menstrual cramps, the use of domestic luteinizing hormone-producing hormone (LRH) agonistic analogs, [D-propyl 6, demyramide ~ (10)] (LRH-A) 0.5mg / day (10 cases) and 1.0mg / day (18 cases) by nasal spray to spray even 21 days, stopping 7 to 10 days for the period of one drug interval Administration method, observed a total of 50 drug cycles. The results showed that the subjects during the medication E_2, P, and LH levels were inhibited, no one pregnancy, withdrawal can quickly return to normal ovulation cycles and sex hormone levels, and no significant side effects, it seems more The use of continuous administration method is excellent, it is worth further clinical observation.