论文部分内容阅读
目的将原格列吡嗪缓释微丸在离心包衣锅中进行上药、包衣改进到流化床中进行,提高生产效率,节约人工及能耗,同时产品各项指标达到质量标准要求。方法不改变原有处方组成,通过2种生产工艺的上药率、体外释放度指标和生产效率的比较,采用正交试验优化生产工艺参数。结果该产品的流化床工艺可行,各项指标达到原工艺的水平,且提高生产效率,节约人工及能耗。结论流化床生产工艺优于离心包衣锅,适合格列吡嗪缓释微丸的生产。
The purpose of the original glipizide sustained-release pellets in the centrifugal coating pan on the drug coating improved into the fluidized bed to improve production efficiency and save labor and energy consumption, while the product quality indicators to meet the standards . The method does not change the composition of the original prescription. The orthogonal design was used to optimize the production process parameters by comparing the two drug production rates, in vitro release index and production efficiency. Results The product of the fluidized bed process feasible, the indicators reached the level of the original process, and improve production efficiency and save labor and energy consumption. Conclusion The fluidized bed production process is superior to centrifugal coating pan, suitable for the production of glipizide sustained-release pellets.