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SorCS1是哺乳动物细胞I型跨膜受体家族成员之一。该家族成员在 N 端有一个共同的Vps10P结构域，均可以与相应的配体结合，在细胞内将蛋白转运到溶酶体，并在包涵体运送到高尔基氏体的运输过程和信号转导方面起重要作用。 SorCS1含有多个亚型，并与慢性肾脏病、阿尔茨海默病、帕金森病、额颞叶变性等神经组织退化性疾病以及糖尿病慢性神经病变的发生有密切的关系。“,”SorCS1 is a type I transmembrane receptor,member of mammalian cell Vps10P family.The members of this family have the same N-terminal domain Vps10P,all of which can bind with corresponding ligands and transport protein intracellularly to lysosomes and play important roles in mediating endosome trans-Golgi and signal transduction.SorCS1 contains multiple subtypes, and has close relationship with chronic kidney disease and Alzheimer disease,Parkinson disease,frontotemporal lobar degeneration and other diabetic neurodegenerative diseases.