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目的观察欣母沛(卡前列素氨丁三醇)用于预防产妇产后出血的疗效。方法 2010年5月—2011年11月收治78例有产后出血倾向的产妇,随机分为治疗组和对照组各39例,两组产妇均采取硬膜外+腰麻,麻醉生效后无需捆绑下肢,采取新式剖宫产手术,打开子宫下段,吸净羊水,待胎儿娩出后立即向宫壁内注射药物。治疗组给予欣母沛250μg注射,对照组注射缩宫素20 U,同时静脉滴注缩宫素10 U。计量资料采用t检验,计数资料采用χ2检验,P<0.05为差异有统计学意义。结果治疗组产后出血率25.6%(10/39),对照组48.7%(19/39),两组比较差异有统计学意义(P<0.05)。治疗组2 h出血量(201.8±50.8)ml、24 h出血量(287.9±62.7)ml,对照组分别为(322.4±58.4)ml、(461.2±73.4)ml,治疗组产后出血量少于对照组(P<0.05)。结论欣母沛用于预防产后出血效果明显,值得在临床中推广。
Objective To observe the effect of Xinmupe (carboprost tromethamine) on preventing postpartum hemorrhage in maternal. Methods From May 2010 to November 2011, 78 pregnant women with postpartum bleeding were randomly divided into treatment group (39 cases) and control group (39 cases). Both groups were given epidural plus spinal anesthesia. After anesthesia did not need to tie the lower extremity , To take a new cesarean section surgery, open the lower uterine segment, suction net amniotic fluid, to be fetus immediately after delivery to the intrauterine injection of drugs. The treatment group was given Xinbo Pei 250μg injection, the control group injected oxytocin 20 U, while intravenous infusion of oxytocin 10 U. Measurement data using t test, count data using χ2 test, P <0.05 for the difference was statistically significant. Results The postpartum hemorrhage rate was 25.6% (10/39) in the treatment group and 48.7% (19/39) in the control group, with significant difference between the two groups (P <0.05). The amount of bleeding in the treatment group was (201.8 ± 50.8) ml for 2 h and that for 24 h was (287.9 ± 62.7) ml in the control group, which was (322.4 ± 58.4) ml and (461.2 ± 73.4) Group (P <0.05). Conclusion Xin Ma Pei for the prevention of postpartum hemorrhage effect is obvious, it is worth promoting in the clinic.