甲状腺乳头状癌基因研究的现状

• 作 者: 傅锦业 吴毅
• 机 构: 复旦大学附属肿瘤医院头颈外科,复旦大学附属肿瘤医院头颈外科 上海200032,上海200032
• 出 处: 外科理论与实践
• 发表日期: 2005年06期
• 关键词: 甲状腺乳头状癌 癌基因 原癌基因 基因 p53

甲状腺肿瘤是头颈外科的常见病之一，其发病率约为 每年1～4/10万，女性多见(男女之比约为1∶2～3) ，且随年龄 增长而发病率有所上升，与种族人群差异、电离辐射暴露、 饮食中碘含量等因素有关。甲状腺乳头状癌(papillary thyroid carcinoma，PTC)是甲状腺肿瘤中最常见的病理类型， 约占全部甲状腺恶性肿瘤的80%。近年统计研究发现 PTC 的发病率有(?)升趋势，可能与环境、饮食等因素有关。

Thyroid neoplasms are one of the most common head and neck surgical diseases. The incidence rate is about 1 to 40 per 100,000 per year. Women are more common (the ratio of men and women is about 1: 2 to 3), and their incidence increases with age , And ethnic differences, ionizing radiation exposure, dietary iodine content and other factors. Papillary thyroid carcinoma (PTC) is the most common pathological type in thyroid tumors, accounting for about 80% of all thyroid malignancies. In recent years, statistical studies found that the incidence of PTC (?) Rising trend may be related to the environment, diet and other factors.