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目的 :探讨肺原发性软骨肉瘤的临床病理特征及组织发生。方法 :通过HE、组化及免疫组化观察 2例肺原发性软骨肉瘤 ,并复习文献。结果 :肿瘤由粘液样基质和疏网状结构的梭形细胞及软骨母细胞组成 ,例 2还存在幼稚小圆细胞 ,三种细胞梯度移行。组化染色显示AB( pH 2 5 )、TB( pH 4 0 )阳性。免疫组化染色显示梭形细胞及软骨母细胞S 1 0 0蛋白、vimentin和NSE阳性 ,例 2Syn阳性。小圆细胞CD99、S 1 0 0蛋白和NSE阳性。 结论 :肺原发性软骨肉瘤的组织发生来自支气管软骨组织和肺原始性间叶组织。临床特征表现肺门和肺两型与预后相关 ,是一种罕见的恶性肿瘤。
Objective : To investigate the clinicopathological features and histogenesis of primary lung chondrosarcoma. Methods: Two cases of primary chondrosarcomas of the lung were observed by HE, histochemistry and immunohistochemistry. The literature was reviewed. RESULTS: The tumor consisted of mucin-like stroma and sparse-net-like spindle cells and chondroblasts. There were also naive small round cells in Example 2, and the three cells migrated in gradients. Histochemical staining showed AB (pH 25) and TB (pH 4 0) positive. Immunohistochemical staining revealed spindle cell and chondrocyte S 1 0 0 protein, vimentin and NSE positive, and 2Syn positive. Small round cells are positive for CD99, S 1 0 0 protein and NSE. Conclusion : The primary histological chondrosarcoma of the lung originates from bronchial cartilage tissue and primary pulmonary mesenchymal tissue. The clinical features of hilar and lung types are associated with prognosis and are rare malignant tumors.