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血管紧张素转化酶(Angiotensinconverting enzyme,ACE) ACE为肽基二肽水解酶EC3.4.15.1,首次于1954年由猪肺中提纯。1974年证明它与以前称为激肽酶I的水解缓激肽的酶为同一物。其基本功能有二: 1.转化活性低的血管紧张素I(A_I)为活性高的血管紧张素Ⅱ(A_Ⅱ)。如下图:
Angiotensin converting enzyme (ACE) ACE is peptidyl dipeptide hydrolase EC3.4.15.1, first purified in 1954 by porcine lung. It was demonstrated in 1974 to be identical to enzymes previously known as kininase I for the hydrolysis of bradykinin. Its basic functions are two: 1 conversion activity of low angiotensin I (A_I) high activity of angiotensin Ⅱ (A_ Ⅱ). As shown below: