日本血吸虫发育过程中副肌球蛋白的免疫定位

• 作 者: 甘燕
• 出 处: 国外医学(寄生虫病分册)
• 发表日期: 1998年02期
• 关键词: 副肌球蛋白 日本血吸虫 湖北钉螺 疫苗研究 靶抗原 小鼠肺 发育阶段 重组蛋白 体被 乙酸双氧铀

在血吸虫疫苗研究中,副肌球蛋白(一种97kDa蛋白)被认为是一种有效的疫苗靶抗原。本文对日本血吸虫各发育阶段副肌球蛋白的免疫定位进行了研究。 各期日本血吸虫分别取自湖北钉螺和感染血吸虫的BALB/c小鼠。压螺收集菲律宾株尾蚴,用尾蚴逸出法收集中国株尾蚴;肺期童虫从感染3天后的小鼠肺部取得;感染40

Paramyosin, a 97-kDa protein, is considered as a potent vaccine target antigen in schistosome vaccine research. In this paper, the immune localization of paramyosin in various developmental stages of Schistosoma japonicum was studied. Each stage of Schistosoma japonicum was taken from BALB / c mice infected with Schistosoma japonicum and Schistosoma japonicum respectively. Colletotrichum cercariae were collected from the Philippines and cercariae of Chinese strains were collected by cercariae escaping; the lungworms were obtained from the lungs of mice 3 days after infection;