论文部分内容阅读
目的探讨慢性阻塞性肺疾病(COPD)急性加重时血液流变学的特点。方法选取58例急性加重期COPD(AECOPD)患者为观察组,予以丹红注射液静脉滴注治疗;将同期入院体检的80例健康志愿者纳入对照组。对比两组受试者入院时血液流变学指标(全血高切黏度、全血低切黏度、红细胞积压、血小板黏附率、血浆黏度、细胞刚性指数)、炎性指标[白细胞介素-6(IL-6)、C反应蛋白(CRP)]及肺功能(FEV1)差异,记录观察组患者治疗前后上述指标变化情况。结果治疗前后,观察组各血液流变学指标及炎性指标均显著高于对照组,肺功能指标低于对照组(P<0.05);治疗后,观察组各血液流变学指标及炎性指标均较治疗前降低,肺功能指标较治疗前升高(P<0.05)。血液流变学指标与IL-6、CRP等呈正相关(P<0.05),与FEV1呈负相关(P<0.05)。结论 COPD急性加重期患者存在血液高凝状态及微血栓形成情况,CRP及IL-6等炎症因子水平同血液流变学指标关系密切,需引起临床重视。
Objective To investigate the characteristics of hemorrheology in patients with chronic obstructive pulmonary disease (COPD) exacerbation. Methods Fifty-eight patients with acute exacerbation of COPD (AECOPD) were selected as the observation group and received intravenous infusion of Danhong injection. Eighty healthy volunteers admitted to the hospital during the same period were included in the control group. The indexes of hemorheology (high shear viscosity, low shear viscosity, erythrocyte backlog, platelet adhesion rate, plasma viscosity, cell rigidity index) and inflammatory indexes [interleukin-6 (IL-6), C-reactive protein (CRP) and pulmonary function (FEV1) were measured before and after treatment in the observation group. Results Before and after treatment, the indexes of hemorheology and inflammatory indexes in the observation group were significantly higher than those in the control group, and the indexes of pulmonary function were lower than those in the control group (P <0.05). After treatment, the indexes of hemorheology and inflammatory The indexes were lower than those before treatment, and the indexes of pulmonary function were higher than those before treatment (P <0.05). The indexes of hemorrheology were positively correlated with IL-6 and CRP (P <0.05), but negatively correlated with FEV1 (P <0.05). Conclusion The hypercoagulability and microthrombus formation in patients with acute exacerbation of COPD are present. The levels of inflammatory cytokines such as CRP and IL-6 are closely related to hemorheological parameters, which needs clinical attention.