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本文用失血性休克大鼠离体左房观察了促甲状腺素释放激素（ｔｈｙｒｏｔｒｏｐｉｎｒｅｌｅｎｓｉｎｇｈｏｒ－ｍｏｒｅ，ＴＲＨ）对肾上腺素能和多巴胺受体激动剂正性肌力作用的影响，用全细胞记录式膜片钳制技术研究了ＴＲＨ对豚鼠单一心肌细胞慢钙内流的作用及对肾上腺素能和多巴胺受体激动剂促钙内流作用的影响。结果显示，ＴＲＨ本身对失血性休克大鼠离体左房仅有轻微的正性肌力作用，但却可增强异丙肾上腺素和多巴胺的正性肌力作用，但不增强苯肾上腺素的正性肌力作用。表明ＴＲＨ对休克大鼠心脏β－肾上腺素能和多巴胺受体具有一定的增敏作用。ＴＲＨ可延长豚鼠单一心肌细胞的钙通道开放时间，增强异丙肾上腺素和多巴胺的促钙内流作用，这可能是ＴＲＨ增敏心脏β和ＤＡ受体，增加其受体激动剂正性肌力作用的重要原因。
In this study, the effects of thyrotropin releasing hormone-more (TRH) on the inotropic effect of adrenergic and dopamine receptor agonists were observed in isolated left atrium of hemorrhagic shock rats. Whole-cell recording films Clamped technique was used to study the effects of TRH on slow calcium influx in guinea pig single cardiomyocytes and the effect of adrenergic and dopamine receptor agonists on calcium influx. The results showed that TRH alone had a slight positive inotropic effect on isolated left atrium in hemorrhagic shock rats, but it could enhance the positive inotropic effect of isoproterenol and dopamine, but not enhance the positive of phenylephrine Muscle function. It shows that TRH has a certain sensitizing effect on β-adrenergic and dopamine receptors in the heart of shock rats. TRH can prolong the calcium channel opening time of single cardiomyocytes in guinea pigs and enhance the calcium influx of isoproterenol and dopamine. This may be due to TRH sensitizing cardiac β and DA receptors and increasing their positive inotropic agonist Important role of the reason.