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ＢＡＬＢ／Ｃ小鼠５５只，经鼻滴入呼吸道合胞病毒悬液１００μｌ（１０６ＰＦＵ）引起小鼠肺炎。用潘生丁（５０ｍｇ／ｋｇ·ｄ）于不同时间（感染前１天、感染同时及感染后１天）和不同剂量（１００、２５、１２．５ｍｇ／ｋｇ·ｄ）灌胃，共３天。通过病理学和组织化学方法观察鼠肺和脾脏，发生感染后１天（５０ｍｇ／ｋｇ·ｄ）给药组肺泡炎最轻，上皮细胞内病毒颗粒少，浆细胞数量多，脾动脉周围淋巴鞘Ｔ淋巴细胞增殖最轻。提示适量口服潘生丁通过抑制炎症早期Ｔ淋巴细胞增殖，促进分泌特异性抗体的浆细胞生成，减轻免疫损伤使病情改善。
Fifty-five BALB / C mice were challenged with pneumonia by intranasal instillation of 100 μl of respiratory syncytial virus suspension (106 PFU). The rats were treated with dipyridamole (50 mg / kg · d) at different times (one day before infection, at the same time of infection and one day after infection) and different doses (100, 25 and 12.5 mg / kg · d) for 3 days. The pathological and histochemical methods were used to observe the lung and spleen of the mice. The alveolitis was the lightest at 1 day (50mg / kg · d) after infection and the number of virus particles in the epithelial cells was less than that in the control group T lymphocyte proliferation the lightest. Prompt oral dipyridamole by an appropriate amount of early inhibition of T lymphocyte proliferation and promote the secretion of specific antibody plasma cells, reduce immune damage to improve the condition.