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目的对比观察重度有机磷农药中毒合并呼吸衰竭患者采用长托宁(盐酸戊乙奎醚)与阿托品治疗的临床效果。方法将我院2010年1月~2013年1月接待的重度有机磷农药中毒合并呼吸衰竭患者51例作为研究对象,皆进行了气管插管与呼吸机控制呼吸。根据患者及家属自愿随机原则分为研究组与对照组,对照组25例患者,采用阿托品治疗,研究组26例患者,采用长托宁治疗。对比分析两组患者拔管脱机时间、住院时间、并发症发生情况、胆碱酯酶恢复时间及治愈与病死情况。结果经过治疗后,比较组及研究组患者在前述评价指标上各有其优缺点,但长托宁多数指标优于对照组患者,差异性显著(P<0.05或0.01),有统计学意义。结论重度有机磷农药中毒合并呼吸衰竭患者,合理应用阿托品及长托宁治疗极为重要,可以取得比较良好的效果,长托宁相较于阿托品治疗而言,有着疗效更高、并发症更少、病死率更低等优势。
Objective To compare the clinical effects of penehyclidine hydrochloride and atropine in patients with severe organophosphorus pesticide poisoning and respiratory failure. Methods Fifty-one patients with severe organophosphorus pesticide poisoning and respiratory failure admitted in our hospital from January 2010 to January 2013 were enrolled in this study. Both endotracheal intubation and ventilator-controlled respiration were performed. According to the random and random principle of patients and their families, they were divided into study group and control group, 25 patients in control group were treated with atropine, and 26 patients in study group were treated with penehyclidine hydrochloride. The extubation time, hospitalization time, complication, recovery time of cholinesterase and cure and death were compared between the two groups. Results After treatment, the comparison group and the study group had their own advantages and disadvantages in the above evaluation indexes, but the scores of the other parameters were better than those in the control group (P <0.05 or 0.01). Conclusion Severe organophosphorus pesticide poisoning patients with respiratory failure, the rational use of atropine and changitonine treatment is extremely important, you can get a better effect, compared with atropine treatment of long tetany, has a higher efficacy, fewer complications, Lower mortality and other advantages.