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目的探讨胸腔镜下肺癌根治术患者手术前后的血小板参数及血流变指标的变化。方法选取2010年3月-2012年8月进行胸腔镜下肺癌根治术的29例患者为观察组,同期的29名健康人员为对照组,将观察组术前、术后3 d、7 d和对照组的血小板参数及血流变指标进行比较。结果观察组术前和术后3 d PLT、PCT、PDW及血浆黏度、全血黏度、血细胞比容均显著高于对照组,MPV则显著低于对照组,P均<0.05,差异均有统计学意义,而术后7 d两组上述指标差异均无统计学意义,P均>0.05。结论胸腔镜下肺癌根治术患者手术前后的血小板参数及血流变指标呈现一定的波动,但最终可达到较为正常的状态,因此可有效反应疾病的变化。
Objective To investigate the changes of platelet parameters and hemorrheological indexes before and after thoracoscopic surgery for lung cancer. Methods 29 patients undergoing thoracoscopic radical resection of lung cancer from March 2010 to August 2012 were selected as observation group and 29 healthy persons as control group during the same period. The patients in observation group were treated with preoperative and postoperative 3 d, 7 d and The control group’s platelet parameters and the indexes of blood rheology were compared. Results The PLT, PCT, PDW, plasma viscosity, whole blood viscosity and hematocrit in the observation group before and 3 days after operation were significantly higher than those in the control group and MPV was significantly lower than those in the control group (all P <0.05) However, there was no significant difference in the above indexes between the two groups on the 7th day postoperatively (all P> 0.05). Conclusions The platelet parameters and hemorrheological indexes in patients undergoing thoracoscopic radical resection of lung cancer show some fluctuations before and after operation, but eventually they can reach a more normal status, which can effectively reflect the changes of the disease.