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引起哮喘的常见因素是对于吸入抗原的一种变态反应。但在易感人群中,虽无特异性的多种刺激物(如酸气、冷空气、运动及病毒感染)也可以引起支气管收缩。致病因素(特异或非特异的)是否使支气管对其它刺激物呈过敏反应而本身并不引起哮喘发作,还不清楚。最近的研究表明,成人及儿童的一个致喘因素是胃食管返流。与胃内容物被吸出有关的严重胃食管返流能导致复发性肺炎、支气管炎,甚至肺纤维
A common cause of asthma is an allergic reaction to inhaled antigens. However, in the susceptible population, although no specific multiple stimuli (such as acid gas, cold air, exercise and viral infection) can also cause bronchoconstriction. It is unclear whether the causative agent (specific or nonspecific) causes an allergic reaction of the bronchial tube to other irritants, without itself causing an asthma attack. Recent studies have shown that one of the causes of asthma in adults and children is gastroesophageal reflux. Severe gastroesophageal reflux associated with the aspiration of gastric contents can lead to recurrent pneumonia, bronchitis, and even pulmonary fibrosis