论文部分内容阅读
目的 探讨细胞核因子 κB(NF κB)与大肠癌发生、转移和治疗的关系。方法 采用文献回顾的方法对NF κB的结构和分子生物学特性 ,以及与细胞凋亡、恶性肿瘤、大肠癌的关系进行综述。结果 NF κB具有抗凋亡作用 ,与恶性肿瘤的发生、转移密切相关 ,并通过对原癌基因 (c myc)、环氧合酶 (Cox2 )、细胞间粘附分子 (ICAM 1 )的调控 ,影响大肠癌的发生、转移。结论 NF κB对大肠癌的发生、转移具有重要作用 ,是大肠癌治疗的新靶点
Objective To investigate the relationship between nuclear factor κB (NF κB) and the occurrence, metastasis and treatment of colorectal cancer. Methods The literature review was used to review the structural and molecular biological characteristics of NF κB, as well as its relationship with apoptosis, malignant tumors and colorectal cancer. Results NFκB had anti-apoptotic effects and was closely related to the occurrence and metastasis of malignant tumor. Through the regulation of c-myc, Cox2, ICAM-1, Affect the occurrence and metastasis of colorectal cancer. Conclusion NF κB plays an important role in the carcinogenesis and metastasis of colorectal cancer and is a new target for the treatment of colorectal cancer