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采用免疫组织化学SABC（链霉亲合素-生物素化过氧化物酶反应）方法，检测了32例胆管癌及3例胆管腺瘤组织中p53蛋白的表达状况。结果：前者p53蛋白的表达率为30％，后者均阴性；p53蛋白表达与癌细胞组织学类型、淋巴结转移及肿瘤部位均无相关性。本实验结果提示：p53蛋白参与了胆管癌的演变，但有关在胆管癌中具体的临床意义有待进一步研究。
Immunohistochemical SABC (streptavidin-biotinylated peroxidase reaction) method was used to detect the expression of p53 protein in 32 cases of cholangiocarcinoma and 3 cases of cholangiocarcinoma. RESULTS: The expression rate of p53 protein in the former was 30%, and the latter was negative. There was no correlation between p53 protein expression and the histological type, lymph node metastasis, and tumor site of cancer cells. The results of this experiment suggest that p53 protein is involved in the evolution of cholangiocarcinoma, but the specific clinical significance in cholangiocarcinoma remains to be further studied.