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目的:探讨控制性超促排卵(COH)周期中注射hCG日与取卵(OPU)后48 h雌激素(E2)下降幅度与体外受精-胚胎移植(IVF-ET)结局的关系。方法:回顾性分析1 271个IVF/ICSI-ET助孕周期患者hCG注射日和OPU后48 h时血清E2水平,并根据血清E2下降幅度、年龄及助孕结局分组比较。结果:①E2下降幅度在未妊娠组、早期流产组和继续妊娠组间无统计学差异(P>0.05)。②hCG注射日与OPU后48 h E2下降幅度>80%时,胚胎着床率和临床妊娠率均明显下降(P<0.05),早期流产率无明显变化(P>0.05)。结论:hCG注射日与OPU后48 h E2下降>80%时,影响子宫内膜容受性,胚胎着床率及临床妊娠率下降,但不增加早期流产率。
OBJECTIVE: To investigate the relationship between estrogen (E2) decline and the outcome of in vitro fertilization-embryo transfer (IVF-ET) 48 h after hCG injection and OPU injection in a controlled ovarian hyperstimulation (COH) cycle. Methods: Serum E2 levels were analyzed retrospectively on 1 271 IVF / ICSI-ET gestational cycles on the day of hCG injection and 48 h after OPU. The levels of serum E2, age, and pregnancy outcomes were compared. Results: (1) There was no significant difference in the decrease of E2 between the non-pregnant group, the early abortion group and the continuous pregnancy group (P> 0.05). (2) The embryo implantation rate and clinical pregnancy rate decreased significantly (P <0.05) at the 48th day after the injection of hCG and the 48 hours after OPU. The rate of early miscarriage did not change significantly (P> 0.05). CONCLUSION: The endometrial receptivity, embryo implantation rate and clinical pregnancy rate decreased after hCG injection and E2 decreased 48% at 48 h after OPU, but did not increase the rate of early miscarriage.