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目的:了解乙肝病毒宫内感染新生儿主被动联合免疫的免疫成功率和失败率,评价主被动联合免疫的效果。方法:选取乙肝病毒携带孕妇分娩的宫内感染新生儿54例,乙肝病毒携带孕妇分娩的非宫内感染新生儿134例和正常孕妇分娩的新生儿164例,观察各组的免疫成功率和免疫失败率。结果:乙肝病毒携带孕妇分娩的非宫内感染的婴幼儿,免疫成功率为77.05%,免疫失败率为22.95%;正常孕妇分娩的婴幼儿,免疫成功率为88.67%,免疫失败率为11.33%;乙肝病毒携带孕妇分娩的婴幼儿,免疫成功率为59.18%,免疫失败率为40.82%。结论:主被动联合免疫对乙肝病毒宫内感染新生儿起到了积极的保护作用,但仍存在较高的失败率。
Objective: To understand the success rate and failure rate of primary and passive immunization of neonates with intrauterine HBV infection and to evaluate the effect of primary and secondary combined immunization. Methods: Fifty-four newborns with intrauterine infection during delivery of hepatitis B virus and 134 newborns with non-intrauterine infection due to hepatitis B virus infection and 164 newborns delivered by normal pregnant women were enrolled. The success rate of immunization and immunization Failure rate. Results: The success rate of immunization was 77.05% and the rate of immune failure was 22.95%. The success rate of immunization in infants and young children who were delivered by normal pregnant women was 88.67% and the rate of immune failure was 11.33% ; Hepatitis B virus-carrying pregnant women delivered infants and young children, the immune success rate was 59.18%, the immune failure rate was 40.82%. Conclusion: Active and passive combined immunization has a positive protective effect on newborns with intrauterine infection of HBV, but there is still a high failure rate.