论文部分内容阅读
MicroRNA是一类通过影响RNA表达、抑制蛋白质翻译来调节基因表达的内源性非编码小分子RNA。自从2014年首次发现苏丹型和扎伊尔型埃博拉病毒能够编码microRNA以来,不断有研究发现新的病毒microRNA以及其在埃博拉病毒复制、扩散、免疫逃逸中发挥的作用。宿主microRNA则参与到抗病毒防御机制中,但也面临着病毒蛋白对其调控的阻力包括相应宿主microRNA水平的变化以及RNA沉默抑制子的编码。深入研究埃博拉病毒与宿主在microRNA水平上的动态相互作用,有利于进一步了解埃博拉病毒的致病机制以及开发新的诊断、治疗策略。本文就microRNA在埃博拉病毒感染中的作用做一简要综述。
MicroRNAs are a class of endogenous, non-coding small RNAs that regulate gene expression by affecting RNA expression and inhibiting protein translation. Since it was first discovered in 2014 that Sultan and Zairian-type Ebola viruses are capable of encoding microRNAs, there has been a continuous search for new viral microRNAs and their role in Ebola replication, spread, and immune escape. Host microRNAs are involved in antiviral defense mechanisms, but are also faced with the resistance that viral proteins regulate, including changes in the corresponding host microRNA levels and coding of RNA silencing suppressors. In-depth study of the dynamic interaction between Ebola and the host at the microRNA level will help to further understand the pathogenesis of Ebola and to develop new diagnostic and therapeutic strategies. This article reviews the role of microRNAs in Ebola virus infection.