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目的评价ＩＦＮ对丙肝患者病毒血症水平的作用．方法竞争性逆转录聚合酶链反应（ＣＲＴＰＣＲ）法定量检测１２例慢性ＨＣＶ感染者（男８例，女４例，ＨＣＶＲＮＡ阳性，ＡＬＴ异常持续６个月以上）ＩＦＮ治疗（ＩＦＮａ２ｂ３ＭＵ，肌注，３次／周，疗程３个月）前后（随访６个月）血清ＨＣＶＲＮＡ水平．结果慢性ＨＣＶ感染者１２例，３例呈完全反应，６例呈部分反应，另外３例无反应．９例有反应者中４例复发，有反应者治疗结束时血清ＨＣＶＲＮＡ水平明显下降（５１７±０４０８ｖｓ２０６±１５５，１０ｃｏｐｉｅｓ／５０μｌｓｅｒｕｍ，ｘ±ｓ，Ｐ＜００５），无反应者血清ＨＣＶＲＮＡ水平未见明显下降（５６７±０５８ｖｓ４５±０８７，ｘ±ｓ，Ｐ＞００５）．３例完全反应者仅１例血清ＨＣＶＲＮＡ持续阴性，３例无反应者２例血清ＨＣＶＲＮＡ水平略有下降．结论ＩＦＮ治疗丙肝有效，但ＩＦＮ不能有效清除病毒，仅抑制病毒复制，未见治疗前血清ＨＣＶＲＮＡ水平与复发与否有关．
Objective To evaluate the effect of IFN on the level of viraemia in hepatitis C patients. Methods A total of 12 patients with chronic HCV infection (8 males and 4 females, positive for HCVRNA and abnormal ALT for more than 6 months) were treated with IFN-γ (IFN2b3MU) by competitive PCR (reverse transcription-polymerase chain reaction) Intramuscular injection, 3 times / week, 3 months course of treatment) (follow-up 6 months) serum HCVRNA levels. Results Of the 12 patients with chronic HCV infection, 3 showed complete response, 6 showed partial response and the other 3 showed no response. Of the 9 responders, 4 were relapsed, and the levels of serum HCVRNA were significantly decreased at the end of treatment (517 ± 0408 vs206 ± 155, 10copies / 50μlserum, x ± s, P <005) There was no significant difference in serum HCVRNA levels between the two groups (567 ± 058 vs45 ± 087, χ ± s, P> 005). Only one of the three responders had persistent negative HCV RNA, and two of three non-responders had a slight decrease in serum HCVRNA. Conclusion IFN treatment of hepatitis C effective, but IFN can not effectively remove the virus, only inhibit viral replication, no serum HCVRNA levels before treatment and relapse or not.