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为探讨内毒素/脂多糖(LPS)、肿瘤坏死因子-α(TNF-α)及一氧化氮(NO)在重型病毒性肝炎(SH)病程中的作用,观察了 SH 患者的器官系统功能状态及其与外周血 LPS、TNF-α、NO 水平变化的关系,同时观察了糖皮质激素对其的影响。现将结果报道如下:一、资料与方法1.59例肝炎患者诊断均符合1990年全国病毒性肝炎会议修订的诊断标准。27例 SH 组中,无发生Ⅱ期肝性脑病和肝肾综合征者9例(NHE 组),仅合并有Ⅱ期以上肝性脑病者11例(HE组),并发有Ⅱ期以上肝性脑病和肝肾综合征者7例(MSF 组);男性18例,女性9例;年龄23～51岁。慢性病毒性肝炎32例(CH组);男性22例,女性10例;年龄20～57岁。2.全部患者入院时及
To investigate the role of endotoxin / lipopolysaccharide (LPS), tumor necrosis factor-α (TNF-α) and nitric oxide (NO) in the pathogenesis of severe viral hepatitis (SH), the functional status of organ in SH patients And its relationship with the changes of peripheral blood LPS, TNF-α, NO levels, while observing the glucocorticoid on its impact. The results are reported as follows: First, the data and methods 1.59 cases of hepatitis patients are in line with the diagnostic criteria of the National Conference on Hepatitis Revised in 1990. 27 cases of SH group, no occurrence of hepatic encephalopathy Ⅱ and hepatorenal syndrome in 9 patients (NHE group), only with 11 cases of secondary hepatic encephalopathy in 11 cases (HE group), accompanied by more than two stages of hepatic Encephalopathy and hepatorenal syndrome in 7 cases (MSF group); 18 males and 9 females; aged 23 to 51 years. Chronic viral hepatitis in 32 cases (CH group); 22 males and 10 females; aged 20 to 57 years. 2. All patients admitted to hospital