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类固醇和硫唑嘌呤治疗 HBsAg 阳性的慢性活动性肝炎(CAH)的长期疗效仍不肯定。本文报告101例经活检证实的 HBsAg 阳性的 CAH,病程均在1年以上。随意分为治疗组:①强的松20mg/日(23例);②硫唑嘌呤100mg/日(29例);③强的松20mg/日加硫唑嗓呤50mg/日(24例).对照组:多种维生素B2片/日(25例)。各组病人的肝功能、肝组织学和HBcAg 的阳性率均类似。在开始治疗时和治疗后2,6,12个月测定 HBsAg,HBcAg 和相应的抗体,观察其血清浓度的变化。
Long-term efficacy of steroids and azathioprine in the treatment of HBsAg-positive chronic active hepatitis (CAH) remains uncertain. This article reports 101 cases of biopsy confirmed HBsAg-positive CAH, duration of more than 1 year. Randomly divided into treatment group: ① prednisone 20mg / day (23 cases); ② azathioprine 100mg / day (29 cases); ③ prednisone 20mg / day plus thiazole pyrazine 50mg / day (24 cases). Control group: multivitamin B2 tablets / day (25 cases). The liver function, liver histology and HBcAg positive rate in all groups were similar. HBsAg, HBcAg and corresponding antibodies were measured at the beginning of treatment and at 2, 6 and 12 months after treatment, and the changes of serum concentrations were observed.