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20多年前,当人们在人和动物肿瘤组织中发现高浓度的前列腺素(PGs)后,肿瘤与增高的PGs的关系,激发了研究人员进行各种实验和临床研究。越来越多的证据表明抑制PGs合成的非甾体类抗炎药(nonsteroidal anti-inflammatory drugs,NSAIDs)能减少结肠癌的发生与发展。一些研究也表明NSAIDs可减少胃癌及食管癌发生。催化PGs合成的酶为前列腺京内过氧化物合成酶,也称环氧合酶(cy-clooxygenase,COX)。COX有两种同功酶;结构型酶COX-1与诱导型酶COX-2。NSAIDs对肿瘤的抑制作用认为与抑制COX-2有关。
More than 20 years ago, when people found high concentrations of prostaglandins (PGs) in human and animal tumor tissue, the relationship between tumors and elevated PGs inspired researchers to conduct a variety of experimental and clinical studies. There is a growing body of evidence that nonsteroidal anti-inflammatory drugs (NSAIDs) that inhibit the synthesis of PGs can reduce the occurrence and development of colon cancer. Some studies also show that NSAIDs can reduce the occurrence of gastric cancer and esophageal cancer. The enzyme that catalyzes the synthesis of PGs is prostatic intracellular peroxidase, also known as cyclooxygenase (COX). COX has two isozymes; the structural enzyme COX-1 and the inducible enzyme COX-2. The inhibitory effect of NSAIDs on tumor is considered to be related to the inhibition of COX-2.