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作者通过狗口服丙磺舒阻断酸性物质向外周血循环转运的方法来测定肌注马桑内酯1mg/kg,前、后脑脊液中去甲肾上腺素、多巴胺和5-羟色胺的代谢物3-甲氧-4羟苯一乙二醇、高香草酸和5-羟吲哚乙酸的含量改变,以了解三者的更新率。初步结果表明:高香草酸的含量显著下降(P<0.05),5-羟吲哚乙酸的含量有所下降(P>0.05)但无统计学意义,3-甲氧-4羟苯一乙二醇影响不大。
The author of oral administration of probenecid blockade of acidic substances to the peripheral blood circulation to determine intramuscular injection of 1mg / kg of intramuscular lactone, before and after cerebrospinal fluid norepinephrine, dopamine and serotonin metabolites 3-A Oxo-4-hydroxybenzene-ethylene glycol, vanillic acid and 5-oxindole acetic acid content changes in order to understand the update rate of the three. The preliminary results showed that the content of vanillic acid decreased significantly (P <0.05), the content of 5-hydroxyindoleacetic acid decreased (P> 0.05), but there was no statistical significance. The content of 3-methoxy- Alcohol has little effect.