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静脉注射阿霉素,柔红霉素和长春新硷漏出后可引起局部组织毒性反应。损害部位出现疼痛、红肿及进一步发展成严重的皮肤溃疡.这种并发症是由于化学药物治疗所致。本文报道的是博莱霉素皮下注射所引起罕见的反应.一位肥胖妇女,61岁,因患淋巴细胞性白血病而住院.在应用 C-MOPP 及 CHOP 治疗方案后,由于心脏毒性而改用长春新硷、博莱霉素、环已亚硝脲及强地松治疗.在病人开始化疗前给予1 IU 博莱霉素做试验性皮下注射.因无任何不良反应,又在患者的右上臂皮下注入9 IU 博莱霉素,当时患者述有轻度烧灼感,于第二天发生血肿及淤斑样改变.
Intravenous doxorubicin, daunorubicin and vincristine leakage can cause local tissue toxicity. Pain, swelling and further development of severe skin ulcers at the site of the lesion result from chemotherapy. This article reports a rare reaction caused by subcutaneous injections of bleomycin: an obese woman, 61, hospitalized for lymphocytic leukemia, switched to cardiotoxicity after C-MOPP and CHOP regimens Vincristine, bleomycin, cyclosporin and prednisone treatment before the patient started chemotherapy given 1 IU bleomycin experimental subcutaneous injection because of any adverse reactions, but also in the patient’s right arm Subcutaneous injection of 9 IU bleomycin, when the patient described a mild burning sensation, the next day hematoma and ecchymydactychoid changes occurred.