Catalytic asymmetric borane reduction of prochiral ketones using chiral camphor-derived mercapto-alc

• 作 者: 周永贵 侯雪龙 戴立信
• 机 构: Laboratory of Organometallic Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of
• 出 处: Chinese Journal of Chemistry
• 发表日期: 1998年03期
• 关键词: alcohols mercapto chiral asymmetric aromatic matie membered induction slightly h

Easily available D-(+)-camphor-derived chiral mercapto-alcohols 2 and 3 were employed for catalytic asymmetric borane reduction of aromatic ketones. Moderate enantioselectivities with e.e. 20.2-72.1% were obtained with 10 mol% catalyst. Opposite asymmetric induction was achieved when mercapto-alcohols 2 and 3 were used.