论文部分内容阅读
为了解水灾后甲型肝炎（甲肝）的流行动态，在湖北和内蒙古等7个受灾省（自治区，下同）中，于1999年1～4月采集1～25岁正常人群血清14322人份。用酶联免疫吸附试验（ELISA）检测了甲肝抗-HAVIgG，部分抗-HAVIgG阳性血清过一步检查抗-HAVIgM。结果表明，灾区人群甲肝抗体平均阳性率（51.27％）明显高于非灾区（42.21％），首次证明甲肝流行与受灾有联系．甲肝抗体阳性率随年龄增长而升高．除湖北（72.7％）和江西（88.4％）两省外。其亡省的灾区和非灾区1～25岁人群甲肝抗体阳性率均＜50％，属甲肝抗体低屏障区．在松花江流域甲肝抗体水平明显低于1992年的调查结果．首次用检测抗-HAVIgM的方法，在正常人群中证明有散在的甲肝亚临床病例存在（1.1％），7个省无一例外，是隐蔽的传染源。
In order to understand the epidemic situation of Hepatitis A (Hepatitis A) after floods, 14322 serum samples of normal people aged 1-25 were collected from January to April 1999 in seven affected provinces (autonomous regions and the same below) in Hubei and Inner Mongolia. Hepatitis A anti-HAVIgG was detected by enzyme-linked immunosorbent assay (ELISA), and some anti-HAV IgG positive sera were tested for anti-HAVIgM in one step. The results showed that the average prevalence of hepatitis A antibody in the affected areas was significantly higher than that in the non-affected areas (51.27%) (42.21%). It was the first time that the prevalence of hepatitis A was linked with the affected areas. Hepatitis A antibody positive rate increases with age. Except Hubei (72.7%) and Jiangxi (88.4%) provinces. The death toll of Hepatitis A and Hepatitis A antibody in non-plague area and non-plague area were all less than 50%, which was a low barrier area of Hepatitis A antibody. Hepatitis A antibody levels in the Songhua River Basin were significantly lower than those of the 1992 survey. For the first time, anti-HAVIgM was used to detect the presence of scattered sub-clinical cases of hepatitis A (1.1%) in the general population, all of which were hidden sources of infection in seven provinces.