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在人类,镁是细胞内第二多的阳离子。人体内的镁约有1,000毫克分子,60%在骨骼中,39%在细胞间质中(其中20%在骨骼肌中),仅有1%在细胞外。血镁可以波动,而细胞内镁的浓度却始终保持恒定。所以血清镁并非总是细胞内镁浓度的可靠指标。因此,最准确的测量人体镁的方法是肌肉活检技术。镁作为大约300种不同酶的一种活化剂,在其他利用三磷酸腺苷(ATP)作为底物的酶系中具有重要的意义。镁在几种耗能的基本生理过程如肌肉收缩,氧化磷酸化,线粒体功能,细胞膜的通透性及神经肌肉的应激性等方面具有重要的作用。心肌是可兴奋的心肌组织冲动的产生和传导取决于跨膜的电化学势能差。动物实验和临床研究表
In humans, magnesium is the second most common cation in cells. About 1,000 milligrams of magnesium is found in the human body, 60% in bones, 39% in the interstitial cells (20% of which is in skeletal muscle) and only 1% extracellularly. Magnesium can fluctuate, while intracellular magnesium concentration has remained constant. So serum magnesium is not always a reliable indicator of intracellular magnesium concentration. Therefore, the most accurate method of measuring human magnesium is the muscle biopsy technique. Magnesium, as an activator of about 300 different enzymes, has important implications for other enzymes that utilize adenosine triphosphate (ATP) as a substrate. Magnesium plays an important role in several basic energy-consuming physiological processes such as muscle contraction, oxidative phosphorylation, mitochondrial function, cell membrane permeability and neuromuscular stress. The production and conduction of impulsive myocardium impulses in the myocardium depend on the difference in electrochemical potential across the membrane. Animal Experiment and Clinical Study Table