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Claudins是紧密连接蛋白,claudin-6(CLDN6)的表达大部分局限于胚胎和胎儿期组织。以往文献报道基因表达微阵列分析显示,与其他中枢神经系统肿瘤及肉瘤相比,CLDN6在非典型畸胎瘤/横纹肌样瘤(AT/RTs)中表达升高。但是这个结果与中枢神经系统肿瘤中CLDN6免疫组化表达的结果不一致。将CLDN6在胎儿和青少年组织中的表
Claudins are tight junction proteins and the expression of claudin-6 (CLDN6) is largely confined to embryonic and fetal tissue. In the past, microarray analysis of gene expression showed that CLDN6 was upregulated in AT / RTs compared with other CNS tumors and sarcomas. However, this result is inconsistent with the results of immunohistochemical CLDN6 expression in CNS tumors. CLDN6 in Fetal and Adolescent Tissues